Warren Wen Selected Research

Renal Dialysis (Hemodialysis)

1/2024	Difelikefalin in Black/African American Hemodialysis Patients with Moderate-to-Severe Pruritus: Post-hoc Analysis of KALM-1 and KALM-2.
9/2023	The Burden of Pruritus Associated With CKD: A Mixed Methods Analysis Among Patients Undergoing Dialysis.
10/2022	Safety and Effectiveness of Difelikefalin in Patients With Moderate-to-Severe Pruritus Undergoing Hemodialysis: An Open-Label, Multicenter Study.
8/2022	Safety and Tolerability of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis From the Phase 3 Clinical Trial Program.
8/2022	Efficacy of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis of KALM-1 and KALM-2 Phase 3 Studies.
12/2021	Psychometric validation and meaningful change thresholds of the Worst Itching Intensity Numerical Rating Scale for assessing itch in patients with chronic kidney disease-associated pruritus.
1/2021	Self-reported Pruritus and Clinical, Dialysis-Related, and Patient-Reported Outcomes in Hemodialysis Patients.
1/2020	A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus.

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Warren Wen Research Topics

Disease

11	Pain (Aches) 01/2017 - 06/2012
8	Pruritus (Itching) 01/2024 - 01/2020
8	Low Back Pain (Lumbago) 04/2016 - 12/2011
7	Chronic Pain 01/2017 - 05/2013
5	Chronic Renal Insufficiency 01/2024 - 01/2020
3	Dizziness (Lightheadedness) 08/2022 - 07/2015
2	Diarrhea 08/2022 - 01/2020
2	Sleepiness 08/2022 - 07/2015
2	Headache (Headaches) 08/2022 - 07/2015
2	Nausea 08/2022 - 07/2015
2	Vomiting 01/2020 - 07/2015
1	Renal Insufficiency (Renal Failure) 01/2024
1	Infections 01/2024
1	Hyperkalemia 08/2022
1	Body Weight (Weight, Body) 01/2020
1	Sensorineural Hearing Loss 01/2017
1	Deafness (Deaf Mutism) 01/2017
1	Ototoxicity 01/2017
1	Neuralgia (Stump Neuralgia) 11/2015
1	Fatigue 07/2015
1	Constipation 07/2015
1	Osteoarthritis 06/2012

Drug/Important Bio-Agent (IBA)

11	Opioid Analgesics (Opioids)IBA 01/2017 - 12/2011
9	Buprenorphine (Subutex)FDA LinkGeneric 04/2016 - 12/2011
8	Hydrocodone (Dihydrocodeinone)FDA LinkGeneric 01/2017 - 06/2012
5	difelikefalinIBA 01/2024 - 01/2020
5	TabletsIBA 01/2017 - 01/2015
4	Analgesics (Analgesic Drugs)IBA 09/2016 - 06/2012
3	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2017 - 06/2012
1	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2020
1	Morphine (MS Contin)FDA LinkGeneric 01/2017
1	ORALIT (ORS)IBA 12/2014
1	hydrocodone drug combination acetaminophen (Vicodin ES)FDA LinkGeneric 06/2012

Therapy/Procedure

8	Renal Dialysis (Hemodialysis) 01/2024 - 01/2020
3	Activities of Daily Living (ADL) 09/2023 - 12/2014
2	Therapeutics 09/2016 - 01/2015
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2024
1	Pain Management 01/2017
1	Precision Medicine 09/2016
1	Analgesia 01/2015
1	Transdermal Patch 12/2011